{"id":3671,"date":"2026-09-16T11:05:10","date_gmt":"2026-09-16T03:05:10","guid":{"rendered":"https:\/\/www.iaao.ntnu.edu.tw\/?p=3671"},"modified":"2026-09-16T11:05:10","modified_gmt":"2026-09-16T03:05:10","slug":"%e3%80%90%e6%b4%bb%e5%8b%95%e7%b4%80%e5%af%a6%e3%80%91%e5%8f%b0%e5%b8%ab%e5%a4%a7%e8%88%87%e4%b8%ad%e7%a0%94%e9%99%a2%e8%b7%a8%e9%a0%98%e5%9f%9f%e5%90%88%e4%bd%9c%e7%82%ba%e5%b8%ab%e7%94%9f%e6%8f%90","status":"publish","type":"post","link":"https:\/\/www.iaao.ntnu.edu.tw\/?p=3671","title":{"rendered":"\u3010\u6d3b\u52d5\u7d00\u5be6\u3011\u53f0\u5e2b\u5927\u8207\u4e2d\u7814\u9662\u8de8\u9818\u57df\u5408\u4f5c:\u70ba\u5e2b\u751f\u63d0\u4f9b\u7cfb\u7d71\u6027\u57f9\u990a\u8de8\u9818\u57df\u5275\u65b0\u3001\u7814\u7a76\u3001\u77e5\u8b58\uff0f\u5149\u96fb\u5de5\u7a0b\u7814\u7a76\u6240\u66a8\u5b78\u58eb\u5b78\u4f4d\u5b78\u7a0b"},"content":{"rendered":"\n<p class=\"has-medium-font-size 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class=\"has-medium-font-size wp-block-paragraph\"><strong>\u56fa\u614b\u96fb\u6c60\u7684\u672a\u4f86\u767c\u5c55\uff1a\u5132\u80fd\u8207\u7bc0\u80fd \u2014 \u65b9\u7267\u61f7\u535a\u58eb<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u65b9\u7267\u61f7\u535a\u58eb\u70ba\u4e2d\u592e\u7814\u7a76\u9662\u61c9\u7528\u79d1\u5b78\u7814\u7a76\u4e2d\u5fc3\u7814\u7a76\u4eba\u54e1\uff0c\u9577\u671f\u4ee5\u6750\u6599\u79d1\u5b78\u70ba\u6838\u5fc3\uff0c\u81f4\u529b\u65bc\u89e3\u6c7a\u5169\u500b\u73fe\u4ee3\u79d1\u6280\u7684\u95dc\u9375\u9700\u6c42\uff1a\u66f4\u5b89\u5168\u7684\u5132\u80fd\u8207\u66f4\u9748\u654f\u7684\u5149\u611f\u6e2c\u3002\u5728\u5132\u80fd\u9818\u57df\uff0c\u4ed6\u6295\u5165\u5168\u56fa\u614b\u96fb\u6c60\u6750\u6599\u7814\u767c\uff0c\u671f\u671b\u4ee5\u66f4\u7a69\u5b9a\u7684\u56fa\u614b\u96fb\u89e3\u8cea\u53d6\u4ee3\u50b3\u7d71\u92f0\u96fb\u6c60\u4e2d\u76f8\u5c0d\u6613\u71c3\u7684\u6db2\u614b\u96fb\u89e3\u6db2\uff0c\u9032\u4e00\u6b65\u63d0\u5347\u96fb\u6c60\u7684\u5b89\u5168\u6027\u3001\u58fd\u547d\u8207\u4f7f\u7528\u60c5\u5883\u7684\u5f48\u6027\u3002 \u96a8\u8457\u9209\u96e2\u5b50\u96fb\u6c60(SIBs)\u7684\u8208\u8d77,\u9e75\u5316\u7269\u56fa\u614b\u96fb\u89e3\u8cea(Halide-based SSEs) \u56e0\u5176\u9ad8\u96e2\u5b50\u96fb\u5c0e\u7387\u3001\u5bec\u96fb\u5316\u5b78\u7a97\u53e3\u53ca\u512a\u7570\u7684\u6c27\u5316\u7a69\u5b9a\u6027\u800c\u5099\u53d7\u77da\u76ee\u3002\u7136\u800c\uff0c\u50b3\u7d71\u5408\u6210\u65b9\u6cd5\u9762\u81e8\u4ee5\u4e0b\u7f3a\u9ede\uff1a\u9996\u5148\uff0c\u56fa\u76f8\u71d2\u7d50\u6cd5\u7684\u80fd\u8017\u9ad8\u3001\u6642\u9593\u9577\uff0c\u96e3\u4ee5\u9032\u884c\u5927\u898f\u6a21\u751f\u7522\uff1b\u518d\u8005\uff0c\u50b3\u7d71\u6eb6\u5291\u6cd5\u5bb9\u6613\u7522\u751f\u6709\u6a5f\u7269\u6b98\u7559,\u4e14\u96e3\u4ee5\u7cbe\u6e96\u63a7\u5236\u7522\u7269\u7684\u7d14\u5ea6\u8207\u7d50\u6676\u5ea6\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u65b9\u535a\u58eb\u7684\u5408\u6210\u65b9\u6cd5\u7814\u7a76\u89e3\u6c7a\u5927\u591a\u6578\u50b3\u7d71\u5408\u6210\u7684\u554f\u984c\uff0c\u5b83\u76f8\u8f03\u65bc\u50b3\u7d71\u6fd5\u5316\u5b78\u6cd5\u5177\u6709\u9ad8\u7d14\u5ea6\u8207\u64f4\u5c55\u6027\uff0c\u6b64\u6280\u8853\u80fd\u6709\u6548\u6392\u9664\u526f\u7522\u7269,\u4e14\u5177\u5099\u6279\u6b21\u751f\u7522(Scalable)\u7684\u6f5b\u529b\u3002\u518d\u4f86\uff0c\u5176\u64c1\u6709\u5148\u9032\u9451\u5b9a\u80fd\u529b\uff0c\u7d50\u5408\u4e86\u540c\u6b65\u8f3b\u5c04\u6280\u8853(\u5982 X-ray \u5438\u6536\u8b5c)\u6df1\u5165\u5206\u6790\u7d50\u69cb\u6f14\u8b8a\u3002\u9019\u9805\u6280\u8853\u7684\u6838\u5fc3\u662f\u958b\u767c\u4e00\u5957\u91dd\u5c0d\u9e75\u5316\u7269\u96fb\u89e3\u8cea\u7684\u5171\u6c89\u6fb1\u901a\u7528\u7b56\u7565\uff0c\u4e26\u5c0e\u5165\u539f\u4f4d(In situ)\u5206\u6790\u6280\u8853\u3002\u4e26\u7d50\u5408\u5927\u6c23\u654f\u611f\u6027\u76e3\u6e2c\uff0c\u5229\u7528\u539f\u4f4d\u5206\u6790\u8ffd\u8e64\u6750\u6599\u5728\u66b4\u9732\u65bc\u7a7a\u6c23\u6642\u7684\u76f8\u8f49\u8b8a\u904e\u7a0b\uff0c\u63ed\u793a\u4e86\u6c34\u5206\u8207\u6c27\u6c23\u5c0d\u96fb\u89e3\u8cea\u6676\u9ad4\u7d50\u69cb\u7684\u5f71\u97ff\uff0c\u70ba\u56fa\u614b\u96fb\u6c60\u5728\u5be6\u969b\u88fd\u9020\u904e\u7a0b\u4e2d\u7684\u74b0\u5883\u63a7\u5236(\u5982\u624b\u5957\u7bb1\u53c3\u6578\u6216\u4e7e\u71e5\u623f\u9700\u6c42)\u63d0\u4f9b\u79d1\u5b78\u6578\u64da\u652f\u6490\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u5728\u5149\u96fb\u9818\u57df\uff0c\u4ed6\u5247\u805a\u7126\u77ed\u6ce2\u7d05\u5916\uff08SWIR\uff09\u5149\u611f\u6e2c\u5668\u8207\u7d05\u5916 LED\u7b49\u5143\u4ef6\u6750\u6599\uff0c\u8b93\u4eba\u5011\u80fd\u66f4\u6709\u6548\u5075\u6e2c\u8089\u773c\u4e0d\u53ef\u898b\u7684\u7d05\u5916\u5149\uff0c\u76f8\u95dc\u6280\u8853\u53ef\u5ef6\u4f38\u61c9\u7528\u5230\u591c\u8996\u6210\u50cf\u3001\u74b0\u5883\u76e3\u6e2c\u3001\u98df\u54c1\u8207\u6750\u6599\u6aa2\u6e2c\uff0c\u4ee5\u53ca\u667a\u6167\u88fd\u9020\u7684\u5373\u6642\u54c1\u8cea\u63a7\u7ba1\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u65b9\u535a\u58eb\u7684\u8de8\u57df\u7279\u8cea\u5728\u65bc\uff0c\u4ed6\u80fd\u4ee5\u540c\u4e00\u5957\u300c\u6750\u6599\u8a2d\u8a08\u2014\u7d50\u69cb\u89e3\u6790\u2014\u6027\u80fd\u9a57\u8b49\u300d\u7684\u65b9\u6cd5\uff0c\u540c\u6b65\u63a8\u9032\u96fb\u6c60\u8207\u5149\u96fb\u5169\u985e\u6280\u8853\u3002\u5728\u6750\u6599\u9762\uff0c\u4ed6\u64c5\u9577\u900f\u904e\u5316\u5b78\u6210\u5206\u8207\u6676\u9ad4\u7d50\u69cb\u7684\u7cbe\u6e96\u8abf\u63a7\uff0c\u638c\u63e1\u80fd\u91cf\u5728\u6750\u6599\u4e2d\u5982\u4f55\u88ab\u5132\u5b58\u3001\u91cb\u653e\uff0c\u6216\u8f49\u63db\u6210\u53ef\u88ab\u8b80\u53d6\u7684\u5149\u8a0a\u865f\uff1b\u5728\u65b9\u6cd5\u9762\uff0c\u4ed6\u4e5f\u7d50\u5408\u7cbe\u5bc6\u91cf\u6e2c\u8207\u7d50\u69cb\u5206\u6790\u5de5\u5177\uff08\u5982 X \u5149\u76f8\u95dc\u6280\u8853\uff09\u8ffd\u8e64\u6750\u6599\u5728\u4e0d\u540c\u74b0\u5883\u4e0b\u7684\u6f14\u8b8a\uff0c\u64da\u6b64\u56de\u63a8\u6700\u4f73\u914d\u65b9\u8207\u88fd\u7a0b\u7b56\u7565\u3002\u4ee5\u300c\u5132\u80fd\u6750\u6599 \u00d7 \u7bc0\u80fd\/\u611f\u6e2c\u5149\u96fb\u300d\u70ba\u7814\u7a76\u4e3b\u984c\uff0c\u65b9\u535a\u58eb\u5c55\u73fe\u5c07\u80fd\u6e90\u8207\u5149\u96fb\u6574\u5408\u65bc\u540c\u4e00\u6280\u8853\u85cd\u5716\u7684\u8996\u91ce\uff0c\u4e26\u900f\u904e\u6750\u6599\u3001\u88fd\u7a0b\u5230\u5143\u4ef6\u7684\u7cfb\u7d71\u5316\u9a57\u8b49\uff0c\u8b93\u300c\u80fd\u6e90\u300d\u8207\u300c\u611f\u6e2c\u300d\u5f9e\u5404\u81ea\u767c\u5c55\u8d70\u5411\u5f7c\u6b64\u652f\u63f4\uff0c\u6210\u70ba\u63a8\u52d5\u4e0b\u4e00\u4ee3\u79d1\u6280\u7684\u91cd\u8981\u57fa\u790e\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u667a\u6167\u751f\u91ab\u5de5\u7a0b\u63a2\u7d22\u300c\u751f\u8001\u75c5\u6b7b\u300d\u7684\u751f\u547d\u79d1\u5b78 \u2014 \u8463\u5955\u937e\u535a\u58eb<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u8463\u5955\u937e\u535a\u58eb\u662f\u4e2d\u592e\u7814\u7a76\u9662\u5728\u667a\u6167\u751f\u91ab\u5de5\u7a0b\u3001\u5fae\u6d41\u9ad4\u7cfb\u7d71\u8207\u751f\u91ab\u611f\u6e2c\u6280\u8853\u9818\u57df\u7684\u91cd\u8981\u7814\u7a76\u8005\uff0c\u81f4\u529b\u65bc\u4ee5\u5de5\u7a0b\u601d\u7dad\u89e3\u6790\u751f\u547d\u79d1\u5b78\u6838\u5fc3\u554f\u984c\uff0c\u4e26\u5c07\u300c\u751f\u8001\u75c5\u6b7b\u300d\u56db\u5927\u751f\u547d\u8b70\u984c\u8f49\u5316\u70ba\u53ef\u91cf\u6e2c\u3001\u53ef\u9810\u6e2c\u3001\u53ef\u4ecb\u5165\u7684\u7cbe\u6e96\u91ab\u7642\u6280\u8853\u3002\u4ed6\u9577\u671f\u6df1\u5165\u7814\u7a76\u5fae\u6d41\u9ad4\u6676\u7247\u3001\u751f\u91ab\u8a0a\u865f\u5206\u6790\u3001\u81ea\u52d5\u5316\u75be\u75c5\u6aa2\u6e2c\u5e73\u53f0\u8207 AI \u8f14\u52a9\u5065\u5eb7\u76e3\u6e2c\uff0c\u5e0c\u671b\u4ee5\u9ad8\u5ea6\u6574\u5408\u7684\u751f\u91ab\u5de5\u7a0b\u5de5\u5177\uff0c\u63d0\u5347\u75be\u75c5\u65e9\u671f\u8a3a\u65b7\u901f\u5ea6\u8207\u7cbe\u6e96\u5ea6\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u6b64\u6b21\u5206\u4eab\u4e09\u9805\u7814\u7a76\uff0c\u9996\u5148\u662f\u6c23\u9ad4\u5fae\u74b0\u5883\u63a7\u5236 (Gaseous Microenvironments)\uff0c\u7531\u65bc\u50b3\u7d71\u63a7\u5236\u6c27\u6c23\u53ca\u6c2e\u6c23\u7684\u88dd\u7f6e\u9f90\u5927\u4e14\u7f3a\u4e4f\u7a7a\u9593\u7cbe\u78ba\u5ea6\uff0c\u800c\u8463\u535a\u58eb\u5229\u7528\u5177\u900f\u6c23\u6027\u7684 PDMS \u6750\u6599\u8207\u7a7a\u9593\u9650\u5236\u5316\u5b78\u53cd\u61c9\u6cd5\uff0c\u5728\u5fae\u6676\u7247\u5167\u5275\u9020\u7cbe\u6e96\u7684\u6c23\u9ad4\u68af\u5ea6\u3002\u900f\u904e\u6c27\u6c23\u68af\u5ea6\u5be6\u9a57\u767c\u73fe\uff0c\u7d30\u80de\u5177\u6709\u5411\u300c\u4f4e\u6c27\u5340\u57df\u300d\u79fb\u52d5\u4e26\u7522\u751f\u840c\u82bd(Sprouting)\u7684\u73fe\u8c61\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u518d\u8005\u70ba\u7269\u7406\u5fae\u74b0\u5883\u8207\u96fb\u5b50\u6d41\u9053 (Physical Microenvironments)\uff0c\u56e0\u8840\u7ba1\u7d30\u80de\u53d7\u5230\u7684\u526a\u61c9\u529b\u8207\u58d3\u529b\u96e3\u4ee5\u5728\u9ad4\u5916\u5373\u6642\u76e3\u63a7\uff0c\u65bc\u662f\u958b\u767c\u300c\u6db2\u614b\u96fb\u8def (Electrofluidic Circuit)\u300d\uff0c\u5229\u7528\u96e2\u5b50\u6db2\u9ad4(Ionic Liquid)\u7684\u9ad8\u5c0e\u96fb\u6027\u8207\u71b1\u7a69\u5b9a\u6027\uff0c\u5728\u5fae\u6d41\u9053\u4e2d\u5d4c\u5165\u58d3\u529b\u611f\u6e2c\u5668\u3002\u5728\u5be6\u969b\u61c9\u7528\u4e0a\u5247\u80fd\u5920\u5373\u6642\u76e3\u6e2c\u7d30\u80de\u5728\u53d7\u529b\u4e0b\u7684\u7269\u7406\u6027\u8cea\u8b8a\u5316\uff0c\u751a\u81f3\u91cf\u6e2c\u8840\u7ba1\u5728\u4e0d\u540c\u65b9\u5411\u4e0a\u7684\u786c\u5ea6\u3002\u6700\u5f8c\u4e00\u9805\u70ba\u591a\u7dad\u5ea6\u7d30\u80de\u57f9\u990a (Multi-Dimensional Cell Culture)\uff0c\u76ee\u7684\u662f\u5f9e 2D \u57f9\u990a\u9032\u5316\u70ba 3D \u57f9\u990a\uff0c\u7528\u4ee5\u6a21\u64ec\u771f\u5be6\u7d44\u7e54(\u5982\u816b\u7624\u7403\u9ad4 Spheroids)\u3002\u7814\u7a76\u6210\u679c\u662f\u958b\u767c\u51fa\u898f\u6a21\u751f\u6210\u5747\u4e00\u5c3a\u5bf8\u7403\u9ad4\u7684\u5e73\u53f0(\u53ef\u9054 5000 \u500b),\u4e26\u7d50\u5408 3D \u816b\u7624\u7403\u9ad4\u8207 2D\u5167\u76ae\u7d30\u80de\u9032\u884c\u5171\u540c\u57f9\u990a,\u89c0\u5bdf\u764c\u75c7\u5f15\u767c\u7684\u8840\u7ba1\u65b0\u751f\u884c\u70ba\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u9019\u4e9b\u7814\u7a76\u6210\u679c\u5c55\u793a\u4e86\u5982\u4f55\u5c07\u4eba\u9ad4\u8907\u96dc\u7684\u547c\u5438\u8207\u5faa\u74b0\u7cfb\u7d71\u300c\u6a21\u7d44\u5316\u300d\u8207\u300c\u7a4d\u9ad4\u5316\u300d(MIMIC System)\u3002\u672a\u4f86\u900f\u904e\u7d50\u5408 iPSCs(\u8a98\u5c0e\u6027\u591a\u80fd\u5e79\u7d30\u80de)\u6216\u75c5\u4eba\u6aa2\u9ad4\uff0c\u9019\u7a2e\u9ad8\u9810\u6e2c\u529b\u7684\u9ad4\u5916\u6a21\u578b\u5c07\u80fd\u6709\u6548\u6e1b\u5c11\u52d5\u7269\u5be6\u9a57\u7684\u9700\u6c42\uff0c\u4e26\u52a0\u901f\u81e8\u5e8a\u6e2c\u8a66\u7684\u8f49\u5316\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u8463\u535a\u58eb\u7684\u7814\u7a76\u5c55\u73fe\u5f37\u5927\u7684\u8de8\u57df\u6574\u5408\u80fd\u529b\uff0c\u6db5\u84cb\u751f\u7269\u5de5\u7a0b\u3001\u91ab\u5b78\u3001\u751f\u7269\u7269\u7406\u8207\u8cc7\u8a0a\u79d1\u6280\uff0c\u63a8\u52d5\u751f\u91ab\u79d1\u6280\u7531\u300c\u8fa8\u8b58\u75be\u75c5\u300d\u8d70\u5411\u300c\u9810\u6e2c\u8207\u9810\u9632\u300d\u3002\u8463\u535a\u58eb\u7684\u524d\u77bb\u7814\u7a76\u5c07\u6210\u70ba\u53f0\u7063\u667a\u6167\u91ab\u7642\u3001\u9577\u7167\u79d1\u6280\u8207\u7cbe\u6e96\u5065\u5eb7\u5e03\u5c40\u4e2d\u4e0d\u53ef\u6216\u7f3a\u7684\u91cd\u8981\u52d5\u80fd\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u5948\u7c73\u79d1\u5b78\u5728\u6211\u5011\u7684\u672a\u4f86\u751f\u6d3b \u2014 \u5f35\u5141\u5d07\u535a\u58eb<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u5948\u7c73\u79d1\u6280\u5c07\u6750\u6599\u5c3a\u5ea6\u7e2e\u5c0f\u5230\u5948\u7c73\u7b49\u7d1a\uff0c\u4f7f\u5176\u5c55\u73fe\u51fa\u8207\u5de8\u89c0\u4e16\u754c\u622a\u7136\u4e0d\u540c\u7684\u7279\u6027\uff0c\u4e26\u5df2\u5ee3\u6cdb\u6539\u8b8a\u6211\u5011\u7684\u751f\u6d3b\u3002\u5f35\u535a\u58eb\u5c08\u6ce8\u65bc\u5948\u7c73\u6750\u6599\u7684\u5149\u96fb\u7279\u6027\u3001\u5948\u7c73\u7d50\u69cb\u8a2d\u8a08\u4ee5\u53ca\u5176\u65bc\u611f\u6e2c\u3001\u751f\u91ab\u8207\u80fd\u6e90\u9818\u57df\u4e4b\u61c9\u7528\uff0c\u7279\u5225\u662f\u5728\u5948\u7c73\u5149\u5b50\u5b78\u3001\u8868\u9762\u96fb\u6f3f\u5171\u632f\u8207\u5948\u7c73\u8584\u819c\u5de5\u7a0b\u65b9\u9762\u5177\u6709\u6df1\u539a\u6210\u679c\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u6b64\u6b21\u6f14\u8aaa\u7684\u7814\u7a76\u6838\u5fc3\u70ba\u7d93\u6fdf\u578b\u5948\u7c73\u88fd\u5716\u6280\u8853\uff0c\u5229\u7528\u76f4\u5f91\u7d04\u6578\u767e\u5948\u7c73\u7684\u805a\u82ef\u4e59\u70ef\u5fae\u7403,\u900f\u904e\u81ea\u7d44\u88dd\u5f62\u6210\u4e8c\u7dad\u7dca\u5bc6\u5806\u7a4d\u9663\u5217\u3002\u9019\u5c64\u5fae\u7403\u9663\u5217\u5c31\u50cf\u5929\u7136\u7684\u5149\u7f69,\u53ef\u7528\u65bc\u5f8c\u7e8c\u7684\u91d1\u5c6c\u6c89\u7a4d\u6216\u8755\u523b\u3002\u5948\u7c73\u7403\u9762\u900f\u93e1\u5fae\u5f71\u6280\u8853(Nanospherical-Lens Lithography)\u662f\u672c\u5834\u8b1b\u5ea7\u7684\u95dc\u9375\u6280\u8853\u3002\u5c07\u5948\u7c73\u7403\u8996\u70ba\u5fae\u5c0f\u900f\u93e1,\u5229\u7528UV\u5149\u71c8\u7ba1(\u7dda\u578b\u5149\u6e90)\u7167\u5c04,\u5149\u7dda\u901a\u904e\u7403\u9ad4\u5f8c\u6703\u7522\u751f\u5149\u5b50\u5948\u7c73\u5674\u6d41,\u5728\u4e0b\u65b9\u5149\u963b\u5c64\u805a\u7126\u51fa\u8d85\u8d8a\u7e5e\u5c04\u6975\u9650\u7684\u5fae\u5c0f\u5716\u6848\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u9664\u4e86\u66dd\u5149\u6280\u8853,\u8b1b\u5ea7\u4e2d\u4e5f\u63d0\u5230\u5982\u4f55\u900f\u904e\u7269\u7406\u8207\u5316\u5b78\u624b\u6bb5\u7cbe\u6e96\u63a7\u5236\u7d50\u69cb\uff0c\u95dc\u65bc\u7269\u7406\u6cd5\u512a\u5316\u6709\u5169\u7a2e\uff0c\u7b2c\u4e00\uff0c\u900f\u904e\u50be\u659c\u89d2\u5ea6\u65cb\u8f49\u57fa\u677f,\u8b93\u91d1\u5c6c\u53ea\u6c89\u7a4d\u5728\u7d50\u69cb\u8868\u9762,\u4e0d\u6703\u9032\u5165\u5b54\u6d1e\u5167\u90e8\u3002\u7b2c\u4e8c\uff0c\u5229\u7528\u6c27\u96fb\u6f3f\u53bb\u9664\u6b98\u7559\u5149\u963b\uff0c\u4e26\u53ef\u85c9\u7531\u63a7\u5236\u8655\u7406\u6642\u9593\u8abf\u6574\u5149\u963b\u5b54\u6d1e\u5c3a\u5bf8\uff08Open PR Hole\uff09\uff0c\u9032\u800c\u7cbe\u6e96\u63a7\u5236\u6700\u7d42\u5948\u7c73\u7d50\u69cb\u7684\u5b54\u5f91\u5927\u5c0f\u3002\u800c\u5316\u5b78\u6cd5\u6574\u5408\u5247\u662f\u5229\u7528\u7121\u6a5f\u5316\u5b78(\u96fb\u5316\u5b78\u6c89\u7a4d)\u8207\u6709\u6a5f\u5316\u5b78(\u5171\u805a\u5408\u7269\u76f8\u5206\u96e2)\u4f86\u958b\u767c\u591a\u6a23\u5316\u7684\u5948\u7c73\u7d50\u69cb\uff0c\u6700\u7d42\u53ef\u88fd\u4f5c\u51fa\u66f4\u5c0f\u7684\u91d1\u5c6c\u5948\u7c73\u5b54\u6d1e\u9663\u5217\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u76ee\u524d\u5f35\u535a\u58eb\u5c08\u6ce8\u65bc\u958b\u767c\u6838\u5fc3\u88fd\u7a0b\u6280\u8853\uff0c\u5229\u7528\u5be6\u9a57\u5ba4\u73fe\u6709\u8a2d\u5099\u843d\u5be6\u88fd\u7a0b\u9032\u884c\u6574\u5408\uff0c\u4e26\u7522\u51fa\u65b0\u578b\u614b\u7d50\u69cb\u3002\u5728\u672a\u4f86\uff0c\u5f35\u535a\u58eb\u7684\u7814\u7a76\u76ee\u6a19\u5c07\u4ee5\u5be6\u73fe\u5948\u7c73\u5143\u4ef6\u7684\u5546\u696d\u61c9\u7528\u6027\u70ba\u4e3b\uff0c\u5c24\u5176\u5e0c\u671b\u53ef\u4ee5\u958b\u767c\u65b0\u4e00\u4ee3\u7684\u7da0\u80fd\u5149\u96fb\u5143\u4ef6\u6216\u662f\u53ef\u4ee5\u5224\u65b7\u75be\u75c5\u521d\u671f\u7684\u751f\u7269\u611f\u6e2c\u5e73\u53f0\u3002 \u6f14\u8b1b\u7684\u6700\u5f8c\uff0c\u5f35\u535a\u58eb\u52c9\u52f5\u5728\u5ea7\u807d\u773e\uff0c\u505a\u79d1\u5b78\u8981\u6709\u5be6\u8e10\u7cbe\u795e\uff0c\u5275\u65b0\u7684\u7d93\u6fdf\u88fd\u7a0b\u662f\u5728\u5be6\u9a57\u5ba4\u88e1\u5617\u8a66\u51fa\u4f86\u7684,\u800c\u975e\u50c5\u5728\u8fa6\u516c\u684c\u524d\u69cb\u601d\uff1b\u5177\u5099\u654f\u92b3\u89c0\u5bdf\uff0c\u4ed4\u7d30\u7814\u8b80\u5be6\u9a57\u7d50\u679c\uff0c\u56e0\u70ba\u95dc\u9375\u5f80\u5f80\u85cf\u5728\u7d30\u7bc0\u4e2d\uff1b\u6700\u5f8c\u9700\u8981\u5927\u81bd\u5275\u610f\uff0c\u56e0\u70ba\u79d1\u5b78\u9032\u6b65\u9700\u8981\u5275\u9020\u529b\u751a\u81f3\u662f\u807d\u8d77\u4f86\u760b\u72c2\u7684\u60f3\u6cd5\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u8abf\u63a7\u75be\u75c5\u72c0\u614b\u4e0b\u7684\u751f\u5b58\u74b0\u5883\uff1a\u85e5\u7269\u905e\u9001\u7cfb\u7d71\u7684\u5275\u65b0\u61c9\u7528 \u2014 \u6797\u923a\u5bb9\u535a\u58eb<\/strong><\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u6797\u535a\u58eb\u7562\u696d\u65bc\u570b\u7acb\u967d\u660e\u5927\u5b78\u751f\u7406\u5b78\u7814\u7a76\u6240\uff0c\u9577\u671f\u81f4\u529b\u65bc\u5948\u7c73\u91ab\u5b78\u3001\u5148\u9032\u85e5\u7269\u905e\u9001\u7cfb\u7d71\u3001\u751f\u91ab\u6750\u6599\u53ca\u518d\u751f\u91ab\u5b78\u7b49\u9818\u57df\u7814\u7a76\uff0c\u4e26\u4ee5\u8de8\u9818\u57df\u6574\u5408\u751f\u7406\u5b78\u3001\u6750\u6599\u79d1\u5b78\u8207\u751f\u7269\u91ab\u5b78\u5de5\u7a0b\u7684\u5275\u65b0\u6210\u679c\u53d7\u5230\u5b78\u754c\u95dc\u6ce8\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u6b64\u7cfb\u7d71\u7684\u76ee\u6a19\u662f\u5c07\u6b63\u78ba\u7684\u7269\u8cea\uff0c\u5728\u6b63\u78ba\u7684\u6642\u9593\uff0c\u9001\u5230\u6b63\u78ba\u7684\u5c0d\u8c61\u6216\u4f4d\u7f6e\u3002\u56e0\u50b3\u7d71\u85e5\u7269\u6613\u53d7\u4eba\u9ad4\u74b0\u5883(\u5982\u80c3\u9178\u3001\u9175\u7d20)\u7834\u58de,\u96e3\u4ee5\u7cbe\u6e96\u5230\u9054\u60a3\u90e8,\u4e14\u6fc3\u5ea6\u6ce2\u52d5\u5927\u3002\u800c\u85e5\u7269\u905e\u9001\u7cfb\u7d71(\u7c21\u7a31DDS)\u5177\u5099\u53ef\u63a7\u6027\uff0c\u80fd\u4fdd\u8b77\u85e5\u7269\u7e5e\u904e\u751f\u7406\u5c4f\u969c(\u5982\u4e0a\u76ae\u7d44\u7e54)\uff0c\u5be6\u73fe\u6a19\u9776\u905e\u9001\u8207\u7de9\u91cb\uff0c\u5f9e\u800c\u6e1b\u5c11\u526f\u4f5c\u7528\u3002DDS\u7684\u8abf\u63a7\u65b9\u5f0f\u5206\u70ba\u5167\u5728\u8207\u5916\u5728\u7684\u523a\u6fc0\u8a98\u5c0e\uff0c\u5167\u5728\u6703\u5229\u7528\u60a3\u90e8\u7279\u6b8a\u7684 pH \u503c\u6216\u9175\u7d20\u89f8\u767c\u91cb\u653e\uff0c\u800c\u5916\u5728\u5247\u900f\u904e\u8fd1\u7d05\u5916\u5149 (NIR)\u3001\u8d85\u97f3\u6ce2\u3001\u78c1\u5834\u7b49\u65b9\u5f0f\u7cbe\u6e96\u958b\u95dc\u85e5\u7269\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u7531DDS\u5ef6\u4f38\u81f3\u7d30\u80de\u7684\u5065\u5eb7\u554f\u984c\uff0c\u6797\u535a\u58eb\u7684\u53e6\u4e00\u9805\u7814\u7a76\u70ba\u91cd\u5851\u7d44\u7e54\u5fae\u74b0\u5883\u3002\u7d30\u80de\u7684\u5065\u5eb7\u53d6\u6c7a\u65bc\u9130\u8fd1\u7684\u300c\u9130\u5c45\u300d\u8207\u300c\u4ea4\u901a\u300d\u3002\u82e5\u7d30\u80de\u662f\u5065\u5eb7\u72c0\u614b\uff0c\u5247\u5448\u73fe\u7684\u6a23\u8c8c\u70ba\u6c27\u6c23\u5145\u8db3\u3001\u71df\u990a\u5747\u8861\u3001\u7d30\u80de\u5916\u57fa\u8cea\u7a69\u56fa\uff1b\u82e5\u662f\u7d30\u80de\u70ba\u751f\u75c5\u72c0\u614b\uff0c\u5247\u6703\u8868\u73fe\u51fa\u7f3a\u6c27\u3001\u6709\u6bd2\u4fe1\u865f\u5206\u5b50\u5806\u7a4d\u3001\u4ee3\u8b1d\u5931\u8861\u3002\u800c\u6797\u535a\u58eb\u5c07DDS\u7cfb\u7d71\u5f15\u5165\u6cbb\u7642\u751f\u75c5\u7684\u7d30\u80de\uff0c\u4e0d\u518d\u53ea\u662f\u6bba\u6b7b\u75c5\u7076\uff0c\u800c\u662f\u900f\u904e DDS \u300c\u91cd\u5851\u300d \u74b0\u5883\uff0c\u6bd4\u5982\u50cf\u4fee\u5fa9\u6f0f\u6c34\u7684\u8840\u7ba1\uff0c\u964d\u4f4e\u6bd2\u6027\u6216\u6062\u5fa9\u4fe1\u865f\u5e73\u8861\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u5176\u4e2d\u904b\u7528DDS\u7684\u4e00\u500b\u5c08\u984c\u662f\u5229\u7528\u300c\u6c2b\u6c23\u5948\u7c73\u7d50\u69cb\u300d\u5c0d\u6297\u80a5\u80d6\uff0c\u56e0\u80a5\u80d6\u6703\u5c0e\u81f4\u8102\u80aa\u7d44\u7e54(ATM)\u767c\u708e\u8207\u4ee3\u8b1d\u5931\u8861\uff0c\u800c\u6c2b\u6c23\u662f\u6975\u4f73\u7684\u6297\u6c27\u5316\u8207\u6297\u767c\u708e\u6c23\u9ad4\uff0c\u4f46\u5176\u6c34\u6eb6\u6027\u5dee\uff0c\u96e3\u4ee5\u5728\u9ad4\u5167\u7dad\u6301\u6fc3\u5ea6\u3002\u6797\u535a\u58eb\u5229\u7528\u80a5\u80d6\u8102\u80aa\u7d44\u7e54\u4e2d\u5e36\u8ca0\u96fb\u7684\u7cd6\u80fa\u805a\u7cd6(GAGs),\u8a2d\u8a08\u5e36\u6b63\u96fb\u7684 SI@PEI-PLGA \u5948\u7c73\u7d50\u69cb,\u900f\u904e\u96fb\u8377\u5438\u5f15\u7cbe\u6e96\u9396\u5b9a\u5167\u81df\u8102\u80aa\uff0c\u4e26\u6301\u7e8c\u5728\u60a3\u90e8\u5c40\u90e8\u4e14\u6301\u7e8c\u5730\u7522\u751f\u6c2b\u6c23,\u5c07\u5de8\u566c\u7d30\u80de\u7531\u767c\u708e\u578b(M1)\u8a98\u5c0e\u8f49\u5411\u4fee\u5fa9\u578b(M2)\uff0c\u6210\u529f\u6539\u5584\u4ee3\u8b1d\u529f\u80fd\u3001\u964d\u4f4e\u767c\u708e,\u9054\u6210\u300c\u514d\u75ab\u5e73\u8861\u300d\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u53e6\u4e00\u500b\u5c08\u984c\u70ba\u5229\u7528\u300c\u4eff\u51b7\u611f\u8584\u8377\u300d\u8a98\u5c0e\u8102\u80aa\u71c3\u71d2\u3002\u4eba\u9ad4\u4e2d\u767d\u8272\u8102\u80aa (WAT)\u80fd\u5132\u5b58\u80fd\u91cf(\u80a5\u80d6\u4e3b\u56e0)\uff0c\u68d5\u8272\u6216\u7c73\u8272\u8102\u80aa (BAT\/Beige)\u5247\u662f\u71c3\u71d2\u7522\u71b1\u3002\u8a98\u5c0e\u7684\u7b56\u7565\u662f\u900f\u904e\u51b7\u523a\u6fc0\u53ef\u8a98\u5c0e\u8102\u80aa\u300c\u8910\u8b8a\u300d(Browning)\uff0c\u4f46\u8b93\u4eba\u9ad4\u9577\u671f\u8655\u65bc\u5bd2\u51b7\u74b0\u5883\u986f\u7136\u4e0d\u5207\u5be6\u969b\u3002\u56e0\u6b64\uff0c\u6797\u535a\u58eb\u53d6\u7528\u8584\u8377\u9187 (Menthol)\uff0c\u4e00\u7a2e\u80fd\u6fc0\u6d3b\u51b7\u611f\u53d7\u9ad4 TRPM8,\u6a21\u64ec\u51b7\u523a\u6fc0\u3002\u52a0\u5165DDS\u8a2d\u8a08\uff0c\u4f7f\u7528\u74b0\u7cca\u7cbe (Cyclodextrin) \u5305\u88f9\u758f\u6c34\u6027\u7684\u8584\u8377\u9187\u63d0\u9ad8\u6eb6\u89e3\u5ea6\uff0c\u4e26\u5d4c\u5165\u53ef\u6eb6\u6027\u6c34\u81a0(Hydrogel) \u4e2d\uff0c\u518d\u900f\u904e\u52d5\u614b\u53ef\u9006\u7684\u5e2d\u592b\u9e7c\u9375(Schiff-base linkage)\u63a7\u5236\u91cb\u653e\u3002\u6700\u7d42\u9054\u5230\u5728\u4e0d\u6539\u8b8a\u74b0\u5883\u6eab\u5ea6\u7684\u60c5\u6cc1\u4e0b\uff0c\u6210\u529f\u8a98\u5c0e\u5be6\u9a57\u9f20\u9ad4\u5167 UCP1 \u86cb\u767d\u8868\u9054\uff0c\u4fc3\u9032\u80fd\u91cf\u6d88\u8017\u8207\u8102\u80aa\u71c3\u71d2\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u6797\u535a\u58eb\u7684\u7814\u7a76\u5c55\u793a\u4e86\u85e5\u7269\u905e\u9001\u7cfb\u7d71\u5df2\u5f9e\u7c21\u55ae\u7684\u300c\u5305\u88dd\u300d\u9032\u5316\u70ba\u80fd\u4e3b\u52d5\u5e72\u9810\u75be\u75c5\u5fae\u74b0\u5883\u7684\u667a\u80fd\u5de5\u5177\u3002\u7121\u8ad6\u662f\u900f\u904e\u5948\u7c73\u6280\u8853\u6539\u5584\u6c2b\u6c23\u6cbb\u7642\u7684\u6548\u80fd\uff0c\u9084\u662f\u5229\u7528\u5316\u5b78\u5de5\u7a0b\u624b\u6bb5\u6a21\u64ec\u751f\u7406\u523a\u6fc0\uff0cDDS \u6b63\u5728\u70ba\u80a5\u80d6\u8207\u764c\u75c7\u514d\u75ab\u6cbb\u7642\u958b\u62d3\u5168\u65b0\u7684\u8def\u5f91\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\"><strong>\u6750\u6599\u79d1\u6280\u7684\u7a81\u7834\uff1a\u4e8c\u7dad\u6750\u6599\u8207\u5149\u96fb\u5143\u4ef6\u7684\u61c9\u7528 \u2014 \u6797\u6642\u5f65\u535a\u58eb<\/strong> <\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u6797\u6642\u5f65\u535a\u58eb\u662f\u4e2d\u592e\u7814\u7a76\u9662\u61c9\u7528\u79d1\u5b78\u7814\u7a76\u4e2d\u5fc3\u7684\u7814\u7a76\u54e1 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\u6975\u4f73\u7684\u6b50\u59c6\u63a5\u89f8\u3002\u904e\u53bb\u6587\u737b\u8a8d\u70ba\uff0c\u91d1\u7684\u529f\u51fd\u6578\u975e\u5e38\u9ad8,\u5728\u50b3\u7d71\u5143\u4ef6\u7269\u7406\u7406\u8ad6\u4e2d,\u5b83\u61c9\u8a72\u4e0d\u9069\u5408\u7528\u4f86\u4f5c\u70ba n \u578b MoS2\u901a\u9053\u7684\u63a5\u89f8\u91d1\u5c6c,\u56e0\u70ba\u5169\u8005\u80fd\u968e\u4e0d\u5339\u914d,\u7406\u8ad6\u4e0a\u6703\u7522\u751f\u6975\u9ad8\u7684\u8096\u7279\u57fa\u80fd\u969c\u3002\u4f46\u6797\u535a\u58eb\u5718\u968a\u7684\u7d42\u6975\u7a81\u7834\uff0c\u900f\u904e\u5f15\u5165\u51e1\u5fb7\u74e6\u5916\u5ef6\u7684\u55ae\u6676\u92bb\u70ef(Antimonene)\u6216\u512a\u5316\u88fd\u7a0b\u6280\u8853(Polycrystalline Au)\uff0c\u6253\u7834\u4e86\u9019\u500b\u65e2\u5b9a\u4e8b\u5be6\uff0c\u6700\u7d42\u5728 100\u00b0C\u7684\u6eab\u548c\u88fd\u7a0b\u4e0b,\u91d1\u96fb\u6975\u6210\u529f\u5c55\u73fe\u51fa\u8d85\u4f4e\u7684\u63a5\u89f8\u96fb\u963b,\u7834\u9664\u50b3\u7d71\u9ad8\u529f\u51fd\u6578\u91d1\u5c6c\u7121\u6cd5\u505a\u6b50\u59c6\u63a5\u89f8\u7684\u8ff7\u601d\u3002<\/p>\n\n\n\n<p class=\"has-medium-font-size wp-block-paragraph\">\u518d\u4f86\u7b2c\u4e8c\u500b\u7a81\u7834\u662f\u5c11\u5c64 MoS2 \u4f9d\u7136\u80fd\u63d0\u4f9b\u6975\u9ad8\u7684\u5149\u96fb\u5c0e\u589e\u76ca\u3002\u904e\u53bb\u6587\u737b\u8a8d\u70ba\uff0c\u96d6\u7136 MoS2 \u7684\u5149\u5438\u6536\u4fc2\u6578\u5f88\u9ad8\uff0c\u4f46\u7576\u5b83\u5f9e\u55ae\u5c64\u8b8a\u6210\u5c11\u5c64(Few-layer)\u6642\uff0c\u80fd\u9699\u6703\u5f9e\u76f4\u63a5\u80fd\u9699\u9000\u5316\u6210\u9593\u63a5\u80fd\u9699\uff0c\u79d1\u5b78\u5bb6\u666e\u904d\u8a8d\u70ba\u9019\u6703\u5c0e\u81f4\u5b83\u7121\u6cd5\u63d0\u4f9b\u8db3\u5920\u591a\u7684\u5149\u6fc0\u767c\u96fb\u5b50\uff0c\u9032\u800c\u7121\u6cd5\u64c1\u6709\u9ad8\u5149\u96fb\u5c0e\u589e\u76ca\u3002\u800c\u6797\u535a\u58eb\u5718\u968a\u5728\u5149\u96fb\u5143\u4ef6\u7684\u5be6\u4f5c\u4e0a\u8b49\u5be6\uff0c\u53ea\u8981\u4ecb\u9762\u63a7\u5236\u5f97\u7576\u3001\u7f3a\u9677\u964d\u5230\u6700\u4f4e\uff0c\u5c11\u5c64\u6750\u6599\u5728\u5be6\u969b\u5149\u96fb\u61c9\u7528\u4e2d\u311d\u4f9d\u7136\u80fd\u767c\u63ee\u9a5a\u4eba\u7684\u5149\u96fb\u8f49\u63db\u6548\u7387\uff0c\u6253\u7834\u5b78\u8853\u754c\u76f2\u76ee\u8ffd\u6c42\u300c\u4e00\u5b9a\u8981\u7d55\u5c0d\u55ae\u5c64\u300d\u7684\u8a8d\u77e5\u3002<\/p>\n\n\n\n<p 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